Almost any shelled mollusk can, by natural processes, produce some kind of "pearl" when an irritating microscopic object becomes trapped within the mollusk's mantle folds, but the great majority of these "pearls" are not valued as gemstones. Nacreous pearls, the best-known and most commercially-significant pearls, are primarily produced by two groups of molluscan bivalves or clams. A nacreous pearl is made from layers of nacre, by the same living process as is used in the secretion of the mother of pearl which lines the shell. A "natural pearl" is one that forms without any human intervention at all, in the wild, and is very rare. Many hundreds of pearl oysters or pearl mussels have to be gathered and opened, and thus killed, in order to find even one wild pearl, and for many centuries that was the only way pearls were obtained. This was the main reason why pearls fetched such extraordinary prices in the past. A cultured pearl, on the other hand, is one that has been formed on a pearl farm. In modern times however, almost all the pearls for sale were formed with the aid of human pearl farmers. The great majority of pearls on the market are cultured pearls.